Carolyn S. Glaubensklee, Ph. D.
Education Ph.D., Medical Science, Physiology, 1985, University of New Mexico School of Medicine,
Dissertation title: Involvement of Calcium and Calmodulin in the
Regulation of Water Permeability and Anion Transport across the Erythrocyte
Membrane: APossible Defect in Cystic Fibrosis.
M.S., Medical Science, Physiology, 1979, University of New Mexico School of
Medicine.
Thesis Title: Membrane Protein Analysis of Human erythrocytes of the McLeod
Phenotype Utilizing Discontinuous Polyacrylamide Gel Electrophoresis and Freeze
Fracture Electron Microscopy.
B.S., Biology/Chemistry Double Major, 1975, with distinction, University of
Southern Colorado.
Colorado State University-Pueblo/Department of Biology/Visiting Assistant Professor/1999-2004.
The Colorado College/Department of Biology/Assistant Professor/1992-1994/Adjunct Assistant Professor /1994-Present / Pre-Health Advisor/1994-1999/Adjunct Assistant Professor Emeritus/1999
Pikes Peak Community College/Lecturer/ Anatomy & Physiology/1990-1992
UC Berkeley/Physiology-Anatomy/Lecturer/Post Doctoral Associate 1987-1989
UCSF/Cardiovascular Research Institute/Cystic Fibrosis Foundation Fellow 1985-86
Post-doctoral position (CVRI) Training Grant 1986-87
University of New Mexico School of Medicine 1976-1979. Research assistant working on M.S. degree. Position included working on research labs and lecture teaching responsibilities.
USC Biology Department, B.S. Biology and Chemistry, Pueblo, CO. 9/73-9/74.
Student research assistant preparation for physiology laboratories.
Colorado Fuel and Iron Corp. Chemistry Lab., Pueblo, CO. 4/76-8/76
Teaching Principles of Biology-Introduction to Cell Biology/The Human Breast/
Experience Mammology/Vertebrate Physiology/Human Anatomy & Physiology: USC, 1999-present
Vertebrate Physiology-Animal Cell Physiology-Intro to Pharmacology-Cell Biology and Vertebrate Zoology: Colorado College 1992 to present
Bethel College of Nursing, Adjunct Assistant Professor: Guest Lecturer on Cancer & Neoplastic Drugs
Pikes Peak Community College, Lecturer, Cadaver Anatomy & Physiology, 1990-
1992
Physiology 1-Lectures, Fall Semester: UC-Berkeley Physiology Dept. 1988.
Physiology 1-Summer Session: UC-Berkeley Physiology Dept. 1988. (Lecture and
Lab.).
Cell Permeability Labs for Medical Students: Teaching Assistant. UNM Medical
school.
(1979-1981).
Nerve and muscle Instrumentation labs for medical students: Teaching Assistant at UNM Medical School. (1979-1981).
Cardiac Dynamics Lab for medical students: Teaching assistant, UNM (1977-1982).
General Physiology Lectures to Physical Therapists: Lecturer (1983).
GI Lectures to medical students at UNM: Lecturer (1983).
Basic Science Enrichment Lectures: Lecturer (1983).
Lectures I was an invited speaker at the International Cystic Fibrosis Congress in Brighton, England, where I presented my dissertation work. This trip was fully funded by the Congress.
Poster presentation to Trieste, Italy concerning Ph.D. work.
Poster presentation in Vancouver, British Columbia, as part of the American Physiological Society presenting SPQ research as a chloride sensitive probe in cystic fibrosis research.
Research I have participated in cystic fibrosis research investigating membrane dynamics for
Experience approximately seven years. My graduate research was on membrane transport across erythrocyte membranes and the regulation of the process by calcium and calmodulin. I have worked in membrane biophysics using fluorescent dyes as voltage-sensitive
probes to investigate water transport and chloride conductance in the human placenta
of normal and cystic fibrosis tissues. I have become knowledgeable in several
laboratory technique including electophoretic protein separation, transmission and
freeze-fracture EM. Recent experience includes use of the Dionex stopped-flow
spectophotometer for determination of hydraulic water permeability, atomic
absorption for calcium analysis, RIA for detection of calmodulin and have worked on
fluorescent probes utilizing a SLM 480 Fluorimeter interfaced to an IBM PC/XT
computer. I have been involved in using electron paramagnetic resonance to
investigate conformational change in the calmodulin molecule with titration of calcium.
I have also been involved ininvestigation calcium/calmodulin abnormalities as they
relate to sickle cell disease.
Academic Member of the Association of Clinical Anatomists (Sponsored Membership)-1997
Honors &
Fellowships Member of the National Association of Health Professions Advisors:1994-Present
Advisory panel member for the Betz Newsline-A Newsletter for Pre-health Advisors-1996-97.
Cystic fibrosis Fellow, UCSR/CVRI, Fall 1985.
Post-Doctoral Position (2nd Year) Training Grant UCSF/CVRI: 1986-1987.
Strobel Research Grant (ALA) Recipient 1987-1988.
Biophysical Society 1987.
Sigma X membership 1985-current
Cystic Fibrosis Student Traineeship;. Summer, 1980.
UNM Graduate Student Fellowship, Fall, 1979.
Service,
Committees Health Professions Advisor-1994-1999/Colorado College
Faculty Sponsor for the Pre-Health Club on campus--1995-1999/Colorado College
Member of the Neuroscience Advisory Board/Colorado College
Member of the Chem-links Advisory Board/Colorado College
Member of the Human Subject Review Committee for Colorado College
Invited speaker for the College Relations Speaker’s Bureau
Faculty Sponsor for the “Run for Smiles” Benefit run for Operation Smile-1995-1999
USC Vertebrate Zoology Introduction to Pharmacology
Introduction to Holistic Medicine & Human Physiology
Natural Homeopathy
Cell Biology Principles of Biology
Animal Cell Physiology
Mammalogy
Vertebrate Physiology Human Breast Anatomy &
Physiology
Human Anatomy & Physiology Introduction to Cell Biology
New Courses Helped to propose & develop the plans for the new cadaver anatomy & physiology course/CC.
Helped to propose & develop the Wilderness Medicine course taught by Dr. Peter Hudson over the half-block/CC
Helped to propose & develop the Introduction to Pharmacology course/CC
Helped to propose & develop the Introduction to Holistic Medicine & Natural Homeopathy course/CC
Programs Rural Health Internship Program -1994-Present
Developed Involves serveral rural doctors who have volunteered their time & services to
engage our students
Inner City Internship Program-Tentative Start Date Winter 1997
Involves shadowing, volunteer experience, surgical observation
and medical research opportunities in collaboration with
Penrose Hospital
International Medical Internship Program--1997-Present
Student exchange program involving CC
students and students from the UAG in Guadalajara, Mexico and with
St. George’s Medical School in Granada, West Indies.
Students
Gretchen Greer--”How Women Respond to Cold: The Physiology of Prrimary Raynaud’s Phenomenon”--1994:Winner of Presentation Award at the Undergraduate Research Conference in San Diego, CA. Graduated with Distinction.
Eric Kuhn--”Isolation of Norepinephrine and Dopamine Receptor Sites in the Medial
Medulla of the Rat Brain Utilizing Tyrosine Hydroxylase Immunocytochemistry”--
1995-Presented at the Undergraduate Research Conference held in San Francisco,
CA.:
Graduated with Distinction.
Spencer Bonnie--p53 Research in Lung Cancer--Library project.
Chris Erb--”An evaluation of a National Pediatric Health Care Program in Costa Rica:
The fullfillment of the goals of the Carne de salud del nino.”--1997-Graduated with
Distinction.
Crystal Taylor--p53 Research in Cancer: Summer 1997-1999.
Publications C.S. Glaubensklee, A.P. Evan and W.R. Galey: Structural and biochemical analysis of the McLeod erythrocyte membrane. Vox Sang. 42:262, 1982.
C.S. Glaubensklee, and W.R. Galey: Decreased erythrocyte water permeability in cystic fibrosis: Investigation of the role of calcium and calmodulin. In: Calcium-
Binding Proteins. Ec. B. deBernard, et al., Elsevier publishers, New York, NY., 1983.
C.S. Glaubensklee, and W.R. Galey: Calcium and calmodulin are involved in the decreased water permeability of cell membranes in cystic fibrosis, Proc. 9th International Congress on Cystic Fibrosis, Cystic Fiborsis Horizons J. Wiley &
Sons, D. Lawson Editor, 1984 NY, NY.
C.S. Glaubensklee, A.P. Evan and W.R. Galey: Further characterization of the
McLeod erythrocyte, Fed. Proc. 38:1128, 1979.
C.S. Glaubensklee, and W.R. Galey: Erythrocyte osmotic water permeability: investigations on the role of calcium and calmodulin. Fed. Proc. 42(4):
C.S. Glaubensklee, M.A. Zanner and W.R. Galey: Regulation of anion transport
across the erythrocyte of normal and cystic fibrosis individuals. Fed. Proc. 43(4):
4639,1984.
C.S. Glaubensklee, and W.R. Galey: Decreased erythrocyte water permeability in cystic fibrosis: Investigation of the role of calcium and calmodulin. Cystic Fibrosis Club Abstracts, Vol. 24, Pg. 113, 1983.
N. Ilsley, C.S. Glaubensklee, B. Davis and A.S. Verkman: Chloride transport across placental microvillous membranes measured by a chloride-sensitive flourescent probe. Am. J. of Phy. 255 (Cell Physiol 24) C 789-797, 1988.
C.S. Glaubensklee, N. Ilsley, B. Davis and A.S. Verkman: Cystic Fibrosis Research Center, CVRI: Chloride pathway in human placental microvillus membrane vesicles. Biophysical Journal, Feb., 1987. Vol 51 No. 2 part 2 page. 344a.
B. Davis, J. Goodman, N. Ilsley, C.S. Glaubensklee, and A.S. Verkman, UCSF: ATP
and catalytic subunit of protein kinase A stimulate chloride transport in placental microvillus membrane vesicles. North American CF Conference Toronto, Ontario, Canada, Fall 1987. Journal of Pediatric Pulmonology.
GRANTS:
P20-NIH Grant written in conjunction with the University of Colorado Health
Sciences Center—Funded Sept 16th 2002/2005.